I have observed several clients in trials with Sovaldi and ledipasvir. Gilead combined the two and call it Harvoni.
The people setting up the trials went to great lengths to include only the healthiest people and exclude anyone who was not. Even anyone who may possibly have had negative feelings about the drug or negative feelings about life in general.
When they tested Harvoni in people with cirrhosis they chose the healthiest people with the best and brightest outlook on life. I know this as I have observed this for a few years from my client base. I have their lab work, I talk with them on the phone and email with them
frequently so I have a broad picture of how this all works.