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Oxymatrine induces human pancreatic cancer PANC-1 cells apoptosis via regulating expression of Bcl-2 and IAP families, and relea


Oxymatrine, an isolated extract from traditional Chinese herb Sophora Flavescens Ait, has been traditionally used for therapy of anti-hepatitis B virus, anti-inflammation and anti-anaphylaxis. The present study was to investigate the anti-cancer effect of oxymatrine on human pancreatic cancer PANC-1 cells, and its possible molecular mechanism.

2 great articles on OxyMatrine

Among the earliest publications about clinical application of oxymatrine for viral hepatitis was a preliminary study by Li Jiqiang and colleagues, with patients having hepatitis C. Their report, in which positive results were claimed, appeared in Chinese in 1998 (1) and again in English in 1999 (2). They gave oxymatrine injection (600 mg once per day) to patients with hepatitis B, and observed that the viral load declined, indicating that oxymatrine served to inhibit viral replication; in addition it appeared to reduce liver fibrosis.

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