BooksTestimonialsInterviewsLibraryArticlesShop Here 

research

Sunshine hormone, vitamin D, may offer hope for treating liver fibrosis

This image shows mouse liver tissue with fibrosis (red), a type of scarring caused by chronic liver diseases and injuries. Salk researchers found that a drug already approved by the FDA for the treatment of psoriasis deactivates the switch governing the fibrotic response in mouse liver cells, suggesting a potential new therapy for fibrotic diseases in humans. Credit: Salk Institute for Biological Studies Liver fibrosis results from an excessive accumulation of tough, fibrous scar tissue and occurs in most types of chronic liver diseases. In industrialized countries, the main causes of liver injury leading to fibrosis include chronic hepatitis virus infection, excess alcohol consumption and, increasingly, nonalcoholic steatohepatitis (NASH).

Now, in a new study published in the journal Cell, scientists at the Salk Institute for Biological Studies have discovered that a synthetic form of , calcipotriol (a drug already approved by the FDA for the treatment of psoriasis), deactivates the switch governing the fibrotic response in mouse , suggesting a potential new therapy for fibrotic diseases in humans.

New View of Depression: An Ailment of the Entire Body

Scientists are increasingly finding that depression and other psychological disorders can be as much diseases of the body as of the mind.

People with long-term psychological stress, depression and post-traumatic stress disorder tend to develop earlier and more serious forms of physical illnesses that usually hit people in older age, such as stroke, dementia, heart disease and diabetes. Recent research points to what might be happening on the cellular level that could account for this.

Telomere Length Could Predict Cold Virus Infection Risk

Why are some people crippled by colds, while others seem to never get sick? A new study suggests the answer could lie in our telomeres, the DNA "caps" at the end of our chromosomes that protect our genetic information from damage. Each time a cell divides, its telomeres shorten -- and short telomeres have been associated with aging and age-related diseases.

Oxymatrine induces human pancreatic cancer PANC-1 cells apoptosis via regulating expression of Bcl-2 and IAP families, and relea

Background

Oxymatrine, an isolated extract from traditional Chinese herb Sophora Flavescens Ait, has been traditionally used for therapy of anti-hepatitis B virus, anti-inflammation and anti-anaphylaxis. The present study was to investigate the anti-cancer effect of oxymatrine on human pancreatic cancer PANC-1 cells, and its possible molecular mechanism.

Selenium deficiency is associated with insulin resistance in patients with hepatitis C virus–related chronic liver disease

Abstract 

The relationship between selenium (Se) deficiency and insulin resistance has not much been established in persistent hepatitis C virus (HCV) infection, although Se deficiency is often observed in patients with liver cirrhosis. We hypothesized that the decreased serum Se levels were associated with the severity of hepatic fibrosis or insulin resistance in patients with HCV-related chronic liver disease (CLD). To test the hypothesis, 52 patients with HCV-related CLD including chronic hepatitis and liver cirrhosis were enrolled in this study.

Nonresponders to Interferon-based Treatment of HCV Exhibit an Increased Long-Term Hazard of Cirrhosis Compared to Never Treated

The long-term consequences of failed interferon-alpha based hepatitis C treatment on liver morbidity and survival have not been fully explored. We performed retrospective analyses to assess long-term clinical outcomes among treated and untreated patients with hepatitis C virus in two independent cohorts from a United States Veterans Affairs Medical Center and a University Teaching Hospital. Eligible patients underwent liver biopsy during consideration for interferon-alpha based treatment between 1992 and 2007.

Which drinker is most at risk of getting liver disease?

Liver disease is now the fifth biggest killer in the UK — with the number of people dying from it rising by 20 per cent over the past decade. However, there are often no warning signs until it is far advanced, so many of us could have the potentially fatal condition without even realising it.

Indeed, when the British Liver Trust recently offered members of the public on-the-spot screening, one in four people tested showed signs of early scarring.

‘Most people die of liver disease after just their first or second admission to hospital for it, as they have not realised they were suffering with it — and their condition will be so far advanced. By the time they are seen, it is too late,’ says Dr Martin Prince, consultant hepatologist at the Manchester Royal Infirmary.

These people took a test using FibroScan, a device that measures the stiffness of the liver. The technique is similar to ultrasound

These people took a test using FibroScan, a device that measures the stiffness of the liver. The technique is similar to ultrasound

Syndicate content