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The Heat Shock Protein Inhibitor Quercetin Attenuates

The Heat Shock Protein Inhibitor Quercetin Attenuates

Silibinin monotherapy prevents graft infection after orthotopic liver transplantation in a patient with chronic hepatitis C

  from Jules: many studies in the past few years conducted by Peter Ferenci have shown IV silibin to have significant antiviral efficacy against HCV (see link below).

Lloyd's Got A New Book!

Lloyd's Got A New Book!

Hepatitis C is considered an epidemic by the World Health Organization, (WHO) Hepatitis C is the most prevalent liver disease in the world, affecting more than 170 million individuals worldwide.     This is A Program For Living  utilizing Frozen Peptides and Stem Cells,  Supplements and Herbs,  Promising New Supplements,  Foods to Eat, Foods to Avoid &  A Healthy Lifestyle from     Best Selling Author Lloyd Wright tells you how you can treat  Fibrosis, Cirrhosis, Varices, Ascites & Liver Cancer Successfully and Live Well
140 pages paperback

This Program For Living utilizing Frozen Peptides and Stem Cells, 
Supplements and Herbs,  Promising New Supplements, 
Foods to Eat, Foods to Avoid & A Healthy Lifestyle
from Best Selling Author Lloyd Wright
tells you how you can treat 
Fibrosis, Cirrhosis, Varices, Ascites & Liver Cancer
Successfully and Live Well
order yours here | see full cover here

Naringenin inhibits production of hepatitis C virus

Naringenin inhibits the assembly and long-term production of infectious hepatitis C virus particles through a PPAR-mediated mechanism.
Goldwasser J
, Cohen PY, Lin W, Kitsberg D, Balaguer P, Polyak SJ, Chung RT, Yarmush ML, Nahmias Y.

Source

Center for Engineering in Medicine, Shriners Burns Hospital, Boston, MA, USA; Harvard-MIT Division of Health Science and Technology, Cambridge, MA, USA; Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Abstract
BACKGROUND & AIMS:

Hepatitis C virus (HCV) infection affects 3% of the world population and is the leading cause of chronic liver disease worldwide. Current standard of care is effective in only 50% of the patients, poorly tolerated, and associated with significant side effects and viral resistance. Recently, our group and others demonstrated that the HCV lifecycle is critically dependent on host lipid metabolism and that its production is metabolically modulated.

METHODS:

The JFH1/Huh7.5.1 full lifecycle model of HCV was used to study the antiviral effects of naringenin on viral replication, assembly, and production. Activation of PPAR? was elucidated using GAL4-PPAR? fusion reporters, PPRE reporters, qRT-PCR, and metabolic studies. Metabolic results were confirmed in primary human hepatocytes

Heavy Coffee Consumption Linked to Better Hep C Treatment Response

Patients with advanced hepatitis C virus–related liver disease who drank three or more cups of coffee per day were three times more likely to respond to therapy with peginterferon alfa-2a plus ribavirin at four time points than were patients who didn’t drink coffee, Neal David Freedman, Ph.D., and his colleagues reported in the June issue of Gastroenterology.

A Pilot Study of the Grapefruit Flavonoid Naringenin for the Treatment of HCV Infection

View of NCT01091077 on 2010_03_22

ClinicalTrials Identifier:NCT01091077
Updated:2010_03_22

Descriptive Information

Brief title

A Pilot Study of the Grapefruit Flavonoid Naringenin for HCV Infection

Blueberry Leaf Extract w/ Proanthocyanidin

Natural anti-HCV Proanthocyanidins are a potent inhibitor of HCV RNA
expression in extracts of blueberry leaves when examined in an HCV
subgenomic replicon cell culture system.

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