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Russia develops effective drug to treat hepatitis C

Russian scientists have developed an innovative drug that can cure hepatitis C within a month. They started their research in this area over 20 years ago and at present, they have patented the drug which will be available for sale next year.

The drug known as Profetal is based on human alpha-fetoprotein, says Alexander Petrov, head of the Ural Pharmaceutics Cluster, where the project is underway, in an interview with the Voice of Russia.

What Kind of Medical Study Would Have Grandma Believe that Her Daily Multivitamin is Dangerous?

FOR IMMEDIATE RELEASE
Orthomolecular Medicine News Service, October 12, 2011

What Kind of Medical Study Would Have Grandma Believe that Her Daily Multivitamin is Dangerous?

by Robert G. Smith, PhD

(OMNS, Oct 12, 2011) A newly released study suggests that multivitamin and nutrient supplements can increase the mortality rate in older women [1]. However, there are several concerns about the study's methods and significance.

  • The study was observational, in which participants filled out a survey about their eating habits and their use of supplements. It reports only a small increase in overall mortality (1%) from those taking multivitamins. This is a small effect, not much larger than would be expected by chance. Generalizing from such a small effect is not scientific.
  • The study actually reported that taking supplements of B-complex, vitamins C, D, E, and calcium and magnesium were associated with a lower risk of mortality. But this was not emphasized in the abstract, leading the non-specialist to think that all supplements were associated with mortality. The report did not determine the amounts of vitamin and nutrient supplements taken, nor whether they were artificial or natural. Further, most of the association with mortality came from the use of iron and copper supplements, which are known to be potentially inflammatory and toxic when taken by older people, because they tend to accumulate in the body [2,3,4]. The risk from taking iron supplements should not be generalized to imply that all vitamin and nutrient supplements are harmful.

Free, Peer-Reviewed Nutritional Medicine Information Online

FOR IMMEDIATE RELEASE

Orthomolecular Medicine News Service, October 3, 2011

Free, Peer-Reviewed Nutritional Medicine Information Online
No Evidence, Eh?

(OMNS, Oct 3, 2011) Many of our readers
have written to say that when they try to talk to their physician about
using nutritional medicine, the subject is promptly dismissed.
Furthermore, such dismissal is often accompanied with doctor statements
such as, "I have not seen any good research showing that vitamins work
therapeutically."

That your doctor has not seen the research is probably true. However,
the research has been there all along. The problem is that many health
practitioners are often too busy, and sometimes too complacent, to look
for it.

The Heat Shock Protein Inhibitor Quercetin Attenuates

The Heat Shock Protein Inhibitor Quercetin Attenuates

Shark Molecule Kills Human Viruses, Too

A molecule found in sharks appears to be able to wipe out human liver viruses, such as hepatitis, new research has found. 

"Sharks are remarkably resistant to viruses," study researcher Michael
Zasloff, of the Georgetown University Medical Center, told LiveScience.
Zasloff discovered the molecule, squalamine, in 1993 in the dogfish
shark, a small- to medium-size shark found in the Atlantic, Pacific, and
Indian Oceans.

"It looked like no other compound that had been described in any animal
or plant before. It was something completely unique," Zasloff said. The
compound is a potent antibacterial and has shown efficacy in treating
human cancers and an eye condition known as macular degeneration, which
causes blindness.

Silibinin monotherapy prevents graft infection after orthotopic liver transplantation in a patient with chronic hepatitis C

  from Jules: many studies in the past few years conducted by Peter Ferenci have shown IV silibin to have significant antiviral efficacy against HCV (see link below).

Naringenin inhibits production of hepatitis C virus

Naringenin inhibits the assembly and long-term production of infectious hepatitis C virus particles through a PPAR-mediated mechanism.
Goldwasser J
, Cohen PY, Lin W, Kitsberg D, Balaguer P, Polyak SJ, Chung RT, Yarmush ML, Nahmias Y.

Source

Center for Engineering in Medicine, Shriners Burns Hospital, Boston, MA, USA; Harvard-MIT Division of Health Science and Technology, Cambridge, MA, USA; Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Abstract
BACKGROUND & AIMS:

Hepatitis C virus (HCV) infection affects 3% of the world population and is the leading cause of chronic liver disease worldwide. Current standard of care is effective in only 50% of the patients, poorly tolerated, and associated with significant side effects and viral resistance. Recently, our group and others demonstrated that the HCV lifecycle is critically dependent on host lipid metabolism and that its production is metabolically modulated.

METHODS:

The JFH1/Huh7.5.1 full lifecycle model of HCV was used to study the antiviral effects of naringenin on viral replication, assembly, and production. Activation of PPAR? was elucidated using GAL4-PPAR? fusion reporters, PPRE reporters, qRT-PCR, and metabolic studies. Metabolic results were confirmed in primary human hepatocytes

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